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Project

Translocase dynamics of the Type 3 secretion system of enteropathogenic E. coli

The Type III protein secretion system (T3SS) mainly found in gram negative bacteria specializes in delivering bacterial toxins into the cytoplasm of host eukaryotic cells through the injectisome. Once secreted, effectors interfere with host signaling and modulate cellular processes, leading to host cell death. It is responsible for several severe diseases, like the plague (Yersinia pestis), typhoid fever (Salmonella enterica) and infantile diarrhea (Enteropathogenic E. coli; EPEC) leading to millions of annual deaths. The injectisome structure and its function is somehow understood, but still there is a need of research to elaborate the fundamental molecular mechanism of client protein recognition and its passage through injectisome. TranDy aims to identify the assembly and export of translocase through this complex membrane nanomachine. The resulting collective knowledge will significantly impact T3S studies and those of various membrane machines and channels including those in eukaryotic systems important in function and pathologies.

Date:21 Sep 2021 →  31 Mar 2022
Keywords:E coli, Type 3 secretion system
Disciplines:Bacteriology
Project type:PhD project