Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons

Chronic low-grade systemic inflammation is frequently observed in patients with chronic obstructive pulmonary disease (COPD), e.g., elevated pentameric CRP (pCRP). However, pCRP can dissociate to form monomeric CRP (mCRP) which exhibits a clear pro inflammatory behaviour in contrast to the more anti-inflammatory properties of pCRP. Therefore, mCRP may be an informative biomarker to demonstrate chronic low-grade systemic inflammation. This was confirmed by analysing serum samples from 38 patients with COPD and 18 non-COPD control persons (NCCP). mCRP was significantly elevated in patients with COPD vs. NCCP, indicating that mCRP might be considered as a new sensitive marker of chronic low-grade systemic inflammation.

Publication year:2021

Keywords:COPD, pCRP, mCRP, Dlow-grade systemic inflammation

BOF-keylabel:yes

IOF-keylabel:yes

BOF-publication weight:2

Authors:International

Authors from:Higher Education, Hospital

Accessibility:Open