The effect of fluid bolus administration on cerebral tissue oxygenation in post-cardiac arrest patients

Purpose: Fluid boluses (FB) are often used in post-cardiac arrest (CA) patients with haemodynamic instability. Although FB may improve cardiac output (CO) and mean arterial pressure (MAP), FB may also increase central venous pressure (CVP), reduce arterial PaO2, dilute haemoglobin and cause interstitial oedema. The aim of the present study was to investigate the net eect of FB administration on cerebral tissue oxygenation saturation (SctO(2)) in post-CA patients. Methods: Pre-planned sub-study of the Neuroprotect post-CA trial (NCT02541591). Patients with anticipated fluid responsiveness based on stroke volume variation (SVV) or passive leg raising test were administered a FB of 500 ml plasma-lyte A (Baxter Healthcare) and underwent pre- and post-FB assessments of stroke volume, CO, MAP, CVP, haemoglobin, PaO2 and SctO(2). Results: 52 patients (mean age 64 +/- 12 years, 75% male) received a total of 115 FB. Although administration of a FB resulted in a significant increase of stroke volume (63 +/- 22 vs 67 +/- 23 mL, p = 0.001), CO (4,2 +/- 1,6 vs 4,4 +/- 1,7 L/min, p = 0.001) and MAP (74,8 +/- 13,2 vs 79,2 +/- 12,9 mmHg, p = 0.004), it did not improve SctO(2) (68.54 +/- 6.99 vs 68.70 +/- 6.80%, p = 0.49). Fluid bolus administration also resulted in a significant increase of CVP (10,0 +/- 4,5 vs 10,7 +/- 4,9 mmHg, p = 0.02), but did not aect PaO2 (99 +/- 31 vs 94 +/- 31 mmHg, p = 0.15) or haemoglobin concentrations (12,9 +/- 2,1 vs 12,8 +/- 2,2 g/dL, p = 0.10). In a multivariate model, FB-induced changes in CO (beta 0,77; p = 0.004) and in CVP (beta-0,23; p = 0.02) but not in MAP (beta 0,02; p = 0.18) predicted post-FB DSctO(2). Conclusions: Despite improvements in CO and MAP, FB administration did not improve SctO(2) in post-cardiac arrest patients.

Publication year:2021

Keywords:Haemodynamic monitoring, Cardiac arrest, Fluid bolus, Resuscitation, Stroke volume variation

BOF-keylabel:yes

IOF-keylabel:yes

BOF-publication weight:6

Authors from:Higher Education, Hospital

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