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Project

Nanoparticle-modified field-effect sensors for biomarker detection

Immunologically-sensitive field-effect devices (ImmunoFEDs) represent a highly challenging research topic to develop miniaturized immunosensors and immunochips for label-free electrical detection of biomarkers. Usually, an ImmunoFED is constructed by modification of the gate surface with recognition elements (e.g., antibodies) for specific biomarkers (antigens). Since FEDs are surface charge-sensitive devices, and because antibodies and antigens are generally charged in aqueous solutions, formation of an antibody-antigen complex on the gate surface leads to biomarker concentration-dependent changes in the output signal of the FED. Thus, ImmunoFEDs provide a unique possibility for direct electrical detection of biomarkers by their molecular charge. The simplest ImmunoFED consists of a capacitive electrolyte-insulator-semiconductor structure and represents an immuno-sensitive field-effect capacitor (ImmunoFEC). In this work, metallic nanoparticles which are immobilized on the surface of ImmunoFECs will be studied as biomolecule carriers for the detection of biomarkers.

Date:30 Nov 2021 →  Today
Keywords:biosensors, field-effect sensor, metal nanoparticles
Disciplines:Biomedical instrumentation
Project type:PhD project