Deciphering socio-affective communication through ultrasonic vocalizations in rodents: Improving translational research models for neuropsychiatric dysfunctions.

Modeling human neuropsychiatric dysfunctions in rodents is an
extremely daunting challenge, given the subjective nature of many
symptoms, the lack of relevant biomarkers and objective diagnostic
tools, together with the early state of the pertinent neurobiology and
genetics. In fact, the identification of new therapeutic targets is at a
near standstill. I am convinced that a deeper understanding of the
natural rodent behavior repertoire and its relevance for modeling
human neuropsychiatric dysfunctions is needed to overcome current
limitations of translational research. We need to listen to our animal
models. I will improve translational research models for
neuropsychiatric dysfunctions by deciphering socio-affective
communication through ultrasonic vocalizations (USV) in rodents. I
will reach that goal by means of a neuroethology driven strategy
including technological innovations, e.g. a body microphone for
continuous real-time monitoring of USV emission in rats, functionally
validated through ultrasound playback, combined with wireless
electrophysiological recording and stimulation in the brain. This will
allow me to identify new therapeutic targets and to assess the
efficacy of novel treatment approaches for neuropsychiatric
dysfunctions, most notably autism. Deciphering socio-affective
communication through USV in rodents will refine biomedical
research. It will make animal models better.