In-depth characterization of natural killer cell heterogeneity in multiple sclerosis.

Thanks to large-scale genetic studies, animal models and research into the composition of the blood and cerebrospinal fluid of MS patients, the role of specific cells of the innate immune system, the so-called natural killer (NK) cells, in MS is becoming more prominent. The recent development of brand-new techniques such as single-cell RNA sequencing allows us to investigate thousands of cells at the single cell level and identify different subtypes of classical immune cells that may differ significantly in their appearance and function. In this project, we will apply these new techniques to determine the role and diversity of NK cells in MS. Correctly dissecting and defining which subtypes are disease-promoting and which are, on the contrary, protective, is essential to make tomorrow's MS treatments more targeted, efficient and safe.