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Project

Bioceramic materials in the regeneration of dentine-pulp complex

Bioceramic materials, namely, Tricalcium silicate-based cements (TCSC) are known to induce dental pulp stem cell differentiation regulated by a complex network of signalling molecules, pathways, receptors, and transcription control systems. Moreover, TCS cements have now gained great attention within caries management for their biomineralisation (biomemetics) ability as an expression of bioactivity where demineralised dentine tissue could be remineralised. The molecular biology that controls the action mechanism of TCSC remains unclear. This research aims to explore the underlying mechanism in detail and consequently lead to the development of enhanced biomaterials for successful regeneration of dentine-pulp complex.

Date:18 Mar 2022 →  Today
Keywords:Dentine regeneration, Regenerative endodontic therapy, Deep caries, Bioceramic materials
Disciplines:Dental materials and equipment, Stem cell biology, Tissue engineering, Cell signalling, Oral medicine and pathology