European Training Network to Diagnose, Understand and Treat Stargardt Disease, a Frequent Inherited Blinding Disorder - StarT

This project aims to map the cis-regulatory landscape of ABCA4 and to characterize ultraconserved non-coding elements in human retina and retinal pigment epithelium. This is achieved by highresolution chromatin interaction profiling (UMI-4C, HiChIP) and by the integration of multi-omics bulk
and single-cell datasets. Ultimately this may gain insight into missing heritability of inherited retinal diseases (IRD) such as ABCA4-associated disease.