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Mucin histochemistry as a tool to assess rostral digestive tract health in a teleost model (Danio rerio)

Journal Contribution - Journal Article

The zebrafish (Danio rerio), a small agastric teleost fish, has become a popular species to model diseases of the gastrointestinal tract. Remarkably, its rostral digestive tract has been largely understudied. To allow for accurate reporting and to improve the translational potential of this research model, the present study first proposes terminology for the different regions of the rostral digestive tract in zebrafish. Based on markers (in particular mucin histochemistry) which are easy to apply in routine histopathology laboratories, five regions are identified, in line with descriptions for carp, a close relative of zebrafish. The mucin histochemical staining is specific and distinct in each region identified, and can be used as a tool to assess health of the rostral digestive tract. In addition, we identify a transitional zone between the oesophagus and intestinal bulb which may represent a remnant of a rudimentary stomach.
Journal: JOURNAL OF FISH DISEASES
ISSN: 1365-2761
Issue: 12
Volume: 43
Pages: 1603 - 1606
Publication year:2020
Accessibility:Closed