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Solvent-free synthesis of hydrazones and their subsequent N-alkylation in a Ball-mill

Journal Contribution - Journal Article

A large variety of Boc-, Bz-, Ts-, and Fmoc- protected hydrazones were prepared via condensation of an equimolar amount of carbonyl-compound and the corresponding hydrazine using a ball-mill. Hydrazones were always obtained in a quantitative yield and no solvents were used at any step. In a second step, we realized the first solvent-free N-allylation and N-benzylation of these hydrazones.
Journal: Tetrahedron
ISSN: 0040-4020
Issue: 42
Volume: 67
Pages: 8187-8194
Publication year:2011
Accessibility:Open