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Project

Interventional X-ray system equipped with 3D rotational angiography for cardiovascular research in preclinical large animal models.

Current strategies for early treatment of acute coronary
syndromes (i.e. heart attacks) have improved acute survival
but subsequent heart failure and arrhythmias (sudden
cardiac death) are the long-term cause of mortality and
morbidity. Responsible use of large animals as preclinical
translational models remains a cornerstone in
cardiovascular research
and play an irrefutable role in exploratory and validation
research, avoiding a high-risk shortcut from basic research
to randomised clinical trials. In order to be relevant,
translational research in large animal models should be
performed in the same setting as randomised clinical trials.

In large animal models, we can study myocardial
remodelling leading to arrhythmias and heart failure with
extensive imaging and tissue sampling (impossible in
patients), which leads to new fundamental insights and
therapy options. Patients that suffer from a heart attack are
treated in a catheterisation laboratory using an
interventional x-ray system. Novel technology fusing
multimodal medical imaging on an interventional x-ray
system in an augmented reality system, allows for detailed
correlative studies of structural, contractile and
electrophysiological remodelling at the tissue, cell and
molecular level with clinical diagnostic imaging and
interventional methods. In order to preserve and expand
this translational
perspective, we want to acquire an interventional X-ray
system equipped with 3D rotational angiography.

Date:1 May 2022 →  Today
Keywords:interventional X-ray system equipped with 3D rotational angiography, myocardial remodelling, arrhythmias, heart failure, acute coronary syndromes
Disciplines:Diagnostic radiology, Cardiology