Study of the pathogenic mechanisms involved in the Ehlers-Danlos syndrome

The Ehlers-Danlos syndrome (EDS) is a heritable connective tissue disorder characterized by fragility of the connective tissues, mainly affecting the skin, ligaments, joints and blood vessels. This project will focus on the search for new genes underlying clinically well characterized EDS subtypes and on the development of animal models to study the pathogenic mechanisms and to evaluate therapeutic approaches.