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Project

Development of in-vivo relevant dissolution systems for selected neglected-diseases medicines

Functional in-vitro dissolution systems for selected antimalaria and anthelmintic medicines will be developed using biorelevant media and hydrodynamics to dissolve the active drug from the tablet, coupled to caco-2 and parasites to quantify the diffusion permeability. A global IVIV model will be developed, and verified by in-vivo pharmacokinetics.

Date:1 Aug 2014 →  30 Sep 2020
Keywords:antimalaria, biorelevant dissolution, pharmaceutical quality, IVIVR, neglected diseases, anthelmintics, tablets, substandard medicines
Disciplines:Laboratory medicine, Other basic sciences, Regenerative medicine, Biomarker discovery and evaluation, Tropical medicine, Other clinical sciences, Biomaterials engineering, Pharmacology, Other pharmaceutical sciences, Public health services, Bioinformatics and computational biology, Medicinal products, Palliative care and end-of-life care, Chemical product design and formulation, Other translational sciences, Pharmacognosy and phytochemistry, Public health care, Pharmaceutics, Nursing, Scientific computing, Toxicology and toxinology, Other medical and health sciences, Pharmacotherapy, Other health sciences, Other paramedical sciences, Drug discovery and development