Study of fatty acid modification and metabolism on the activity of quorum sensing molecules and lipopeptides produced by Pseudomonas spp.

Pseudomonads produce antimicrobial or cytotoxic cyclic lipopeptides (CLPs) and quorum sensing signal molecules, i.e. N-acyl homoserine lactones (AHLs) as interesting secondary metabolites. The overall goal is a) the identification of the role of AHL-mediated quorum sensing mechanisms in regulating secondary metabolite production (CLPs) and b) the elucidtation of fatty acid-based biosynthetic pathways and SAR of CLPs.