Exploring the role of non-coding variation in hereditary blindness: Stargardt disease as a model

The objective of this study is to unravel the role of non-coding variation in Stargardt disease, a frequent cause of hereditary blindness. First, the regulatory domain of the disease gene will be delineated en characterized. Using next-generation sequencing mutations in this region will be identified, after which they will be filtered using an integrative filtering strategy and several functional tests.