Dissecting the molecular network regulating replacement tooth formation in the zebrafish

In this project, we wish to test the hypothesis that the transcription factor runx functions in an fgf signaling loop to regulate the formation of replacement teeth in zebrafish. We will test this hypothesis by (1) manipulating fgf signaling and studying its effects on runx expression and associated phenotype, and (2) manipulating runx expression itself through gain- and loss-of-function approaches.