Study of mediators and pathways contributing to chronic pain in Ehlers-Danlos syndrome

This project aims to gain more insights into the molecular origins and mechanisms that initiate and maintain chronic pain in Ehlers-Danlos syndrome (EDS). To this purpose, we will study pain-related behavior in EDS animal models, analyse the concomittant changes in innervation and pain pathways and evaluate the pronociceptive potential of extracellular matrix proteins secreted by patient fibroblast cultures.