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Project

Nucleophilic Nanoparticles for optimal delivery of plasmid DNA in dividing cells.

Plasmid DNA needs to reach the cell nucleus to be biologically active. We aim to explore new strategies to target naked DNA or DNA nanoparticles to the cell nuclei of daughter cells during the cell division of the mother cell, since during cell division the intracellular barrier of the nuclear membrane is temporarily broken down.

Date:1 Jan 2009 →  30 Dec 2011
Keywords:plasmid DNA
Disciplines:Biomarker discovery and evaluation, Pharmacology, Process engineering, Chemical product design and formulation, Pharmaceutics, Medicinal products, Pharmacotherapy, Drug discovery and development, Biomaterials engineering, Polymeric materials, Toxicology and toxinology, Other pharmaceutical sciences, Pharmacognosy and phytochemistry