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Project

Preclinical assessment of the therapeutic potential of multitargeting cancer stem cells through modulation of the unfolded protein response and deubiquitinases in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality worldwide. The limited beneficial effects of current treatments make effective therapy a crucial unmet medical need. We aim at unravelling the interconnection of the unfolded protein response (UPR), deubiquitinases (DUBs) and stemness in the pathogenesis of HCC to provide clinically relevant tools for the treatment of this deadly disease.    

Date:1 Oct 2016 →  30 Sep 2020
Keywords:Hepatocellular carcinoma (HCC), endoplasmic reticulum (ER)
Disciplines:Laboratory medicine, Oncology, Palliative care and end-of-life care, Morphological sciences, Systems biology, Other medical and health sciences, Other clinical sciences, Other translational sciences, Other biological sciences, Regenerative medicine, Other basic sciences, Nursing, Other health sciences, Other paramedical sciences