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Project
T-cell plasticity in chronic inflammatory airway diseases.
In this study, T cell plasticity and survival and the role of different damage-associated molecular patterns, prostaglandins, and bacterial superantigens in chronic rhinosinusitis will be studed. The role of the specific mucosal milieu on T cell plasticity will be analyzed in vitro, in vio in Rag2-/-γc-/- knockout mice transplanted with human inflamed mucosa, and ex vivo in human nasal mucosal tissue.
Date:1 May 2010 → 19 Sep 2013
Keywords:inflammation, T regulatory cells, CRS
Disciplines:Immunology, Otorhinolaryngology, Speech, language and hearing sciences