The interactions between sex steroids, bone geometry and body composition in transsexual

Context

Therapy of gender identity disorder induces an altered hormonal milieu.

Design

Prospective intervention study in 100 transsexuals,

cross-sectional study after long-term therapy in 50 female-to-male transsexuals

Objective

To explore the interplay of bone, fat, steroids and metabolism in relation to cross-sex hormonal therapy

Methods

Body composition and bone imaging, serum/tissue hormones, muscle/fat biopsies and mRNA expression of regulating factors