Using Lactococcus lactis to target the intestinal immune system

Enterohemorrhagic Escherichia coli (EHEC) is a human enteric pathogen responsible for diarrhea, hemorrhagic colitis and hemolytic uremia syndrome. Lactococcus lactis, a non colonizing, non pathogenic, bacteria, has been successfully used for mucosal delivery of antigens. In our project recombinant L.lactis will be investigated for their potential to deliver animal models of EHEC infection.