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Locoregional recurrences after transanal total mesorectal excision of rectal cancer during implementation

Journal Contribution - Journal Article

Background Transanal total mesorectal excision (TaTME) has been proposed as an approach in patients with mid and low rectal cancer. The TaTME procedure has been introduced in the Netherlands in a structured training pathway, including proctoring. This study evaluated the local recurrence rate during the implementation phase of TaTME. Methods Oncological outcomes of the first ten TaTME procedures in each of 12 participating centres were collected as part of an external audit of procedure implementation. Data collected from a cohort of patients treated over a prolonged period in four centres were also collected to analyse learning curve effects. The primary outcome was the presence of locoregional recurrence. Results The implementation cohort of 120 patients had a median follow up of 21 center dot 9 months. Short-term outcomes included a positive circumferential resection margin rate of 5 center dot 0 per cent and anastomotic leakage rate of 17 per cent. The overall local recurrence rate in the implementation cohort was 10 center dot 0 per cent (12 of 120), with a mean(s.d.) interval to recurrence of 15 center dot 2(7 center dot 0) months. Multifocal local recurrence was present in eight of 12 patients. In the prolonged cohort (266 patients), the overall recurrence rate was 5 center dot 6 per cent (4 center dot 0 per cent after excluding the first 10 procedures at each centre). Conclusion TaTME was associated with a multifocal local recurrence rate that may be related to suboptimal execution rather than the technique itself. Prolonged proctoring, optimization of the technique to avoid spillage, and quality control is recommended.
Journal: British journal of surgery (Print)
ISSN: 0007-1323
Issue: 9
Volume: 107
Pages: 1211 - 1220
Publication year:2020
Keywords:Hospital, Assen, 6 Zaans Medical Centre, Zaandam, 7 Rode Kruis Hospital, Beverwijk, 8 Noord West Hospital, Alkmaar, 9 Bravis Hospital, Roosendaal, 10 IJsselland Hospital, Cappelle aan den Ijssel, 11 Maxima Medical Centre, Veldhoven, 12 Deventer Hospital, Deventer, 13 Isala Clinic, Zwolle, 14 Dijklander Hospital, Hoorn, 15 Gelderse Vallei Hospital, Ede, and
Accessibility:Open