Dry Run Vaccinopolis.

The Covid pandemic clearly demonstrated the need for faster development of vaccines. A human challenge trial offers the possibility to accelerate the development of vaccines and therapeutics and to gain valuable insights into efficacy early on in development. However, it requires a dedicated facility and highly trained staff to complete these complex clinical trials. Vaccinopolis offers already the possibility to conduct these trials in a one-of-a-kind facility in the world. In total, Vaccinopolis can house 30 volunteers in fully equipped rooms under Biosafety level 3 (BSL-3) conditions. The infrastructure ensures complete control on air, waste water and material flows to prevent any pathogen from escaping the facility or entering the facility in a uncontrolled way. However, in order to increase the confidence among industry and pharma partners even further and to embark on these complex trials, it would be needed to demonstrate safe operation of the facility and train the staff on all the various protocols. Hence, the goal of the project is to mimic a real life human challenge trial and test all the various operational and emergency protocols. Concretely, 20 volunteers will be recruited and will remain in the facility for 3 days. On day 1 and 2, the volunteers will remain in BSL-3 conditions. They represent the most stringent isolation conditions. In this setting also an evacuation with the fire dept will be simulated as well as an medical emergency. At the end of day 2 the conditions will be lowered to BSL-2 containment. In all conditions the operational procedures will be tested and optimized.

Keywords:INNOVATIONS, VACCINE TRIAL

Disciplines:Vaccines