Management of intracellular protein aggregates in stressed bacteria

Given the fundamental importance of protein quality control in cellular physiology and of proteotoxic stresses in the battle against bacterial pathogens, there is an urgent need for a more in depth understanding of the management and impact of intracellular protein aggregates. Using the Escherichia coli bacterium as a highly tractable and relevant model system for both an elementary (prokaryotic) cell and a bacterial pathogen, this project will combine advanced genetics and live cell biology approaches to address the molecular causes and phenotypical consequences of intracellular protein aggregation.