A pre-targeted nanomedicine strategy for in vivo CD8+ T cell engineering.

The goal of this project is to investigate a strategy to pre-target CD8+ T cells in vivo with a chemical moiety that allows for subsequent cellspecific delivery of nanoparticle-formulated therapeutics, functionalized with a complimentary reactive moiety on their surface using ultrafast covalent click chemistry. Via this technology, we aim to modulate T cells in vivo in the blood and in the tumor microenvironment.