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Organisation
Chávez Gutiérrez Lab
Research Group
Main organisation:VIB-KU Leuven Center for Brain & Disease Research
Lifecycle:1 Jul 2017 → Today
Organisation profile:Generating a quantitative understanding of the molecular mechanisms underlying Alzheimer’s disease pathogenicity.
Keywords:Neurobiology, neurodevelopment, neurodegeneration, Alzheimer, Parkinson, ALS
Disciplines:Bioinformatics and computational biology, Molecular and cell biology, Neurosciences
Current researchers
1 - 10 of 10 results
- Chávez-Gutiérrez Lucía (Responsible)
- Mohamed Belal Hamed Soliman (Member)
- Diego Cabezudo (Member)
- Ruggiero Pio Cassatella (Member)
- Sara Gutiérrez Fernández (Member)
- Matthias Koch (Member)
- Ivica Odorcic (Member)
- Caterina Travisan (Member)
- Nicole Wawrzyniak (Member)
- Katarzyna Marta Zoltowska (Member)
Projects
1 - 9 of 9
- Mechanisms of Gamma-Secretase Modulators, towards rational drug design: Mechanisms of Gamma-Secretase Modulators, towards rational drug designFrom1 Aug 2023 → TodayFunding: Other international institutions, not mentioned elsewhere
- Elucidating the mechanisms of action of Gamma-secretase modulators (GSMs) to facilitate structure-based design of nextgeneration therapeuticsFrom1 Jul 2023 → TodayFunding: Foreign foundations, funds with scientific view
- Uncovering the molecular origins of phenotypic complexity linked to Alzheimer's disease causing mutations in presenilin 1From1 Jan 2023 → TodayFunding: Private funding of national origin - undefined
- Untangling the initial mechanisms in Alzheimer’s disease and tackling early pathogenic cellular cascades with NanobodiesFrom1 Jan 2022 → TodayFunding: Private funding of national origin - undefined
- VIB Grant for Chávez Gutiérrez Lab_Period:2022-01-01-2026-12-31From1 Jan 2022 → TodayFunding: FRI - Project driven research
- Abeta Medicated Inhibition of gamma-Secretase Activity Induces AD-Relevant Cellular PhenotypesFrom1 Feb 2019 → 31 Jan 2021Funding: Other international institutions, not mentioned elsewhere
- Molecular chaperones to decipher GSEC-APP interactions and provide mechanistic underpinnings for Alzheimer’s disease therapyFrom1 Jan 2019 → 31 Dec 2020Funding: Private funding of national origin - undefined
- Y-Secretase conformational plasticity, implications for Alzheimer's diseaseFrom1 Jan 2017 → 31 Dec 2018Funding: Private funding of national origin - undefined
- VIB Grant for Chávez Gutiérrez Lab_Period:2017-01-01-2021-12-31From1 Jan 2017 → 31 Dec 2021Funding: FRI - Project driven research
Publications
1 - 10 of 29
- Identification and characterization of Nanobodies targeting the EphA4 receptor(2017)
Authors: Laura Rué Cabré, Lucía Chávez Gutiérrez, Jurgen Haustraete, Gholamreza Hassanzadeh Ghassabeh, Bart De Strooper, Ludo Van Den Bosch, Philip Van Damme, Robin Lemmens
Pages: 11452-11465 - Enzyme-substrate hybrid ß-sheet controls geometry and water access to the ?-secretase active site.(2023)
Authors: Lucía Chávez Gutiérrez
Pages: 670 - A multifactorial model of pathology for age of onset heterogeneity in familial Alzheimer's disease.(2021)
Authors: Lucía Chávez Gutiérrez, Bart De Strooper
Pages: 217-233 - Spastic paraplegia preceding PSEN1-related familial Alzheimer's disease.(2021)
Authors: Maria Szaruga, Lucía Chávez Gutiérrez
Pages: e12186 - Computational Analysis of Alzheimer Amyloid Plaque Composition in 2D- and Elastically Reconstructed 3D-MALDI MS Images.(2020)
Authors: Thomas Enzlein, Lutgarde Serneels, Bart De Strooper, Lucía Chávez Gutiérrez
Pages: 14484-14493 - Exploring the origins of nucleation.(2021)
Authors: Katarzyna Marta Zoltowska, Lucía Chávez Gutiérrez
Pages: e67269 - Prodromal Alzheimer's Disease: Constitutive Upregulation of Neuroglobin Prevents the Initiation of Alzheimer's Pathology.(2020)
Authors: Maria Szaruga, Lucía Chávez Gutiérrez
Pages: 562581 - Alzheimer's-Causing Mutations Shift Abeta Length by Destabilizing gamma-Secretase-Abetan Interactions(2017)
Authors: Maria Szaruga, Sarah Veugelen, Tatjana De Vos, Savvas Savvides, Rodrigo Gallardo, Joost Schymkowitz, Frederic Rousseau, Bart De Strooper, Lucía Chávez Gutiérrez
Pages: 443-456 e14 - TrkA-mediated endocytosis of p75-CTF prevents cholinergic neuron death upon gamma-secretase inhibition.(2021)
Authors: Lucía Chávez Gutiérrez
Pages: e202000844 - Clinical Association of White Matter Hyperintensities Localization in a Mexican Family with Spastic Paraparesis Carrying the PSEN1 A431E Mutation.(2020)
Authors: Lucía Chávez Gutiérrez
Pages: 1075-1083