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Publication

Tissue state and fate in ischemic stroke Insights from MRI

Book - Dissertation

Stroke is a cerebrovascular disorder with a major impact related to both mortality and disability after the event. Brain imaging is always required to differentiate between potential ischemic vs hemorrhagic stroke, which is essential for making therapeutic decisions. After exclusion of brain hemorrhage, thrombolysis and/or mechanical thrombectomy can be initiated aimed at recanalization of the occluded vessel. The major limitation of these treatments is the narrow time window after the stroke occurred. However in some patients the time of onset is unknown and in some patients these strategies might be beneficial after the currently used time windows. Advanced neuro-imaging might be able to determine the status of the brain tissue as a consequence of reduced perfusion; gain some insights in the duration of this perfusion deficit; and potentially predict the outcome of patients. These factors are of importance in guiding physicians in the various treatment options that are available. To clinically rely on the data obtained by this imaging, accuracy and potential confounding factors should be identified and studied. In a large dataset from the WAKE-UP trial we will test several hypotheses related to the value and robustness of data obtained by acute MR (magnetic resonance) imaging. Findings obtained in this project will increase our insights in the role of neuro-imaging in acute stroke. Potentially that could lead to individualized therapy for acute stroke patients.
Publication year:2022
Accessibility:Open