Organisation
Experimental Cardiology
Division
Research focuses on molecular mechanisms of excitation-contraction coupling in cardiac myocytes (electrophysiology, advanced calcium imaging), cellular remodeling in cardiac disease: ischemia and heart failure, mechanisms of arrhythmias. Research further aims to understand epigenetic mechanisms of adaptive and maladaptive remodeling of cardiac myocytes. Other work focuses on molecular pathways in metabolic cardiovascular diseases and biomarkers.
Current researchers
1 - 10 of 17 results
- H Llewelyn Roderick (Responsible)
- Matthew Amoni (Member)
- Konstantinos Chatzieleftheriadis (Member)
- Joshua Jeen Tung Chung (Member)
- Fiona DE MATOS (Member)
- Rosa Donate Puertas (Member)
- Eef Dries (Member)
- Samaneh Ekhteraeitousi (Member)
- David Fajardo (Member)
- Yile Fu (Member)
Projects
1 - 10 of 54
- Deciphering Molecular Pathways of Hypoxia Sensitivity in Adult Cardiomyocytes: An Integrative Cross-Species InvestigationFrom1 Apr 2024 → TodayFunding: Other federal public and semi-governmental institutions
- Human Stem Cell-Derived Cardiac Models to Investigate Cell-Cell Interactions in Epicardial Activation and Cardiac RemodelingFrom1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- A novel ex vivo approach to study local Ca2+-induced triggered activities in ventricular arrhythmias using living adult cardiac slicesFrom1 Sep 2023 → TodayFunding: BOF - tenure track
- Connexin-43 Hemichannels as pro-arythmic mediators in Cardiac Hypertrophy and Heart FailureFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Understanding how neutrophil extracellular traps (NETs) contribute to vulnerability of the ageing heartFrom1 Oct 2022 → TodayFunding: FWO fellowships
- Investigating the role of DNA methylation in the failing and in the ageing heartFrom1 Oct 2022 → TodayFunding: FWO junior postdoctoral fellowship
- Subcellular Ca2+ signalling microdomains regulating cardiomyocyte growth and functionsFrom19 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Interventional X-ray system equipped with 3D rotational angiography for cardiovascular research in preclinical large animal models.From1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Spatially-Organized 3D Human Cardiac Bilayer Models for Duchenne Cardiomyopathy Modelling and Drug DiscoveryFrom23 Nov 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Cell-cell interactions and the role of tissue microarchitecture in cardiac arrhythmias after myocardial infarctionFrom15 Nov 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
331 - 340 of 367
- Steep fall in cardiac output is main determinant of hypotension during drug-free and nitroglycerine-induced orthostatic vasovagal syncopoe(2008)
Authors: Bart Verheyden, Jiexin Liu, Tony Reybrouck, André Aubert
Pages: 1695 - 1701 - Emerging roles of inositol 1,4,5-trisphosphate signaling in cardiac myocytes(2008)
Authors: H Llewelyn Roderick
Pages: 128 - 147 - Reduced mitochondrial respiration in the ischemic as well as in the remote nonischemic region in postmyocardial infarction remodeling(2016)
Authors: Diogo Teodoro Galan, Piet Claus, Eef Dries, Karin Sipido
Pages: H1075 - H1090 - Low-flow support of the chronic pressure-overloaded right ventricle induces reversed remodeling(2018)
Authors: Tom Verbelen, Piet Claus, Daniel Burkhoff, Chandan Kadur Nagaraju, Erik Verbeken, Karin Sipido, Marion Delcroix, Filip Rega, Bart Meyns
Pages: 151 - 160 - Cyclosporine A reduces microvascular obstruction and preserves left ventricular function deterioration following myocardial ischemia and reperfusion(2015)
Authors: Piet Claus, Jan Bogaert, Ronald Driesen, Karin Sipido, Frans Van de Werf
Pages: 18 - Left-ventricular shape determines intramyocardial mechanical heterogeneity(2011)
Authors: Hon Fai Choi, Frank Rademakers, Piet Claus
Pages: H2351 - H2361 - Ventricular Arrhythmias in Ischemic Cardiomyopathy-New Avenues for Mechanism-Guided Treatment(2021)
Authors: Matthew Amoni, Eef Dries, Sebastian Ingelaere, Dylan Vermoortele, H Llewelyn Roderick, Piet Claus, Rik Willems, Karin Sipido
- Whole-Cell Patch Clamp Recordings of Unitary Connexin 43 Hemichannel Currents(2017)
Authors: Maarten De Smet, Karin Sipido
Pages: 189 - 201Number of pages: 13 - Quantitative proteomics and systems analysis of cultured H9C2 cardiomyoblasts during differentiation over time supports a "function follows form' model of differentiation(2018)
Authors: Cynthia Kankeu, H Llewelyn Roderick
Pages: 181 - 196 - Topic modelling based network maps in cardiovascular research(2017)
Authors: Diane Gal, Bart Thijs, Karin Sipido, Wolfgang Glänzel
Pages: 1795 - 1796