Organisation
Laboratory of Biosignaling & Therapeutics
Division
The Laboratory of Biosignaling & Therapeutics investigate cellular signal transduction pathways at the molecular level. One of our major goals is to identify and develop novel biomarkers or therapeutic targets for human diseases. The current focus is on the (mis)regulation of chromatin signaling, DNA repair and cell division in cancer cells by enzymes known as protein phosphatases.
Current researchers
1 - 10 of 11 results
- Mathieu Bollen (Responsible)
- Joao Barbosa (Member)
- Monique Beullens (Member)
- Mathieu Bollen (Member)
- Xinyu Cao (Member)
- Zander Claes (Member)
- Monica Dos Santos Ferreira (Member)
- Marloes Jonkhout (Member)
- Sarah Lemaire (Member)
- Aleyde Van Eynde (Member)
Projects
1 - 10 of 41
- Phospho-regulation at the crossroads of cell proliferation and DNA-damage controlFrom1 Mar 2021 → TodayFunding: Foundations, funds and other with scientific goal
- Coordination of cell-cycle progression and DNA-damage repair by the protein phosphatase-1 regulator NIPP1From1 Mar 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Life-course regulators of protein phosphatase-1From1 Jan 2021 → TodayFunding: FWO research project (including WEAVE projects)
- Host cell phosphatases in the life cycle of DNA virusesFrom1 Oct 2020 → TodayFunding: BOF - projects
- Dual function of SDS22 in the biogenesis of protein phosphatase-1 holoenzymesFrom14 Oct 2019 → 14 Oct 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Role of histone modifications in the life cycle of AAV2 and recombinant AAV-mediated transgene expressionFrom1 Oct 2019 → 27 Jan 2023Funding: FWO Strategic Basic Research Grant, BOF - doctoral mandates
- Chaperone-mediated biogenesis and activity regulation of protein phosphatase-1From3 Sep 2019 → 10 Jan 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Targeting a timer-integrator of cell checkpoint signaling for mesothelioma therapyFrom1 Jan 2019 → 31 Dec 2020Funding: Foundations, funds and other with scientific goal
- Targeting a timer-integrator of cell checkpoint signaling for mesothelioma therapyFrom1 Jan 2019 → 31 Dec 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Molecular timers of the spindle assembly checkpointFrom1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
Publications
41 - 50 of 135
- A Role for PP1/NIPP1 in Steering Migration of Human Cancer Cells(2012)
Authors: Nele Van Dessel, Aleyde Van Eynde, Janina Goernemann, Monique Beullens, Mathieu Bollen
- MELK-Dependent FOXM1 Phosphorylation is Essential for Proliferation of Glioma Stem Cells(2013)
Authors: Monique Beullens
Pages: 1051 - 63 - Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation(2018)
Authors: Mathieu Bollen
Pages: 766 - + - RepoMan stimulates the chromosome-dependent pathway of microtubule assembly(2020)
Authors: Sofie De Munter, Mathieu Bollen
Pages: 3029 - 3041 - The selective inhibition of protein phosphatase-1 results in mitotic catastrophe and impaired tumor growth(2015)
Authors: Claudia Winkler, Sofie De Munter, Nele Van Dessel, Ewald Heroes, Shannah Boens, Monique Beullens, Aleyde Van Eynde, Mathieu Bollen
Pages: 4526 - 37 - Cdk1 orders mitotic events through coordination of a chromosome-associated phosphatase switch(2015)
Authors: Junbin Qian, Monique Beullens, Sofie De Munter, Bart Lesage, Mathieu Bollen
Pages: 10215 - Interactor-guided dephosphorylation by protein phosphatase-1(2013)
Authors: Shannah Boens, Kathelijne Szekér, Aleyde Van Eynde, Mathieu Bollen
Pages: 271 - 81 - De Novo Variants in LMNB1 Cause Pronounced Syndromic Microcephaly and Disruption of Nuclear Envelope Integrity(2020)
Authors: Koenraad Devriendt, Mathieu Bollen, Joris Vermeesch, Hilde Van Esch
Pages: 753 - 762 - Correction: Substrate-specifying determinants of the nucleotide pyrophosphatases/phosphodiesterases NPP1 and NPP2.(2017)
Authors: Anisoara Cimpean, Cristiana Stefan, Rik Gijsbers, Willy Stalmans, Mathieu Bollen
Pages: 4273 - 4274 - Bischoff et al. The Effects of the Food Additive Titanium Dioxide (E171) on Tumor Formation and Gene Expression in the Colon of a Transgenic Mouse Model for Colorectal Cancer(vol12, 1256, 2022)(2023)
Authors: Marloes Jonkhout