Organisation
Laboratory of Computational Biology (VIB-KU Leuven)
Division
Research in the Laboratory of Computational Biology is focusing on gene and genome regulation, with applications in Drosophila and cancer, and on integrative genomics, developing computational methods for genomic data integration and analysis of next-generation sequence data.
Current researchers
1 - 10 of 21 results
- Stein Aerts (Responsible)
- Darina Abaffyová (Member)
- Stein Aerts (Member)
- Sara Aibar Santos (Member)
- Cas Blaauw (Member)
- Carmen Bravo González-Blas (Member)
- Florian De Rop (Member)
- Seppe De Winter (Member)
- Hannah Dickmänken (Member)
- Sam Dieltiens (Member)
Projects
1 - 10 of 64
- Understanding gene regulation in a whole animal: From building a regulatory atlas to decoding gene regulation with deep learningFrom10 Jan 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- SpaceTimeOmics: combining high-throughput spatial omics with AI to model gene regulation in space and timeFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- Interpretation of genomic regulatory variation in the human brain and Parkinson’s Disease by integrating deep learning with single-cell multi-omicsFrom1 Oct 2023 → TodayFunding: FWO junior postdoctoral fellowship
- Deep learning based synthetic design and massively parallel reporter assays to characterize and exploit cell type specific enhancersFrom1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Enhancer-AI: AI-driven modelling and design of cell type specific enhancers for gene therapyFrom1 Oct 2023 → TodayFunding: FWO Strategic Basic Research (SBO)
- Deep learning solutions for deciphering gene regulation in the human brainFrom7 Mar 2023 → TodayFunding: FWO Strategic Basic Research Grant
- The role of smORF encoded polypeptides in lager beer fermentationFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Applications of deep learning for cancer genomicsFrom1 Jan 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Evolution of the genomic regulatory code underlying neuronal diversityFrom1 Oct 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- SymBioSys: Computationally mapping genomic heterogeneity from long read sequencing dataFrom1 Oct 2022 → TodayFunding: BOF - projects
Publications
1 - 10 of 177
- Identification of Circulating Fibrocytes and Dendritic Derivatives in Corneal Endothelium of Patients With Fuchs' Dystrophy(2017)
Authors: An-Katrien De Roo, Jasper Wouters, Olivier Govaere, Beatrijs Foets, Joost van den Oord
Pages: 670 - 681 - CNKSR1 gene defect can cause syndromic autosomal recessive intellectual disability.(2018)
Authors: Ibrahim Ihsan Taskiran
Pages: 691 - 699 - Recurrent rearrangements of FOS and FOSB define osteoblastoma(2018)
Authors: Annelien Verfaillie, Jonas Demeulemeester, Peter Van Loo
- Gene losses in the common vampire bat illuminate molecular adaptations to blood feeding(2022)
Authors: Nikolai Hecker
- iRegulon: From a Gene List to a Gene Regulatory Network Using Large Motif and Track Collections(2014)
Authors: Annelien Verfaillie, Hana Imrichova, Bram Van de Sande, Laura Standaert, Marina Naval Sanchez, Delphine Potier, Dmitry Svetlichnyy, Zeynep Kalender Atak, Mark Fiers, Chris Marine, et al.
- Male-Specific Fruitless Isoforms Target Neurodevelopmental Genes to Specify a Sexually Dimorphic Nervous System(2014)
Authors: Bram Van de Sande, Stein Aerts
Pages: 229 - 241 - Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state(2015)
Authors: Annelien Verfaillie, Hana Imrichova, Zeynep Kalender Atak, Michael Dewaele, Valerie Christiaens, Dmitry Svetlichnyy, Flavie Luciani, Laura Van den Mooter, Sofie Claerhout, Mark Fiers, et al.
- EXPLORING THE CODE OF LIFE: FROM DECODING TO DESIGNING CELL TYPE-SPECIFIC ENHANCERS WITH DEEP LEARNING(2023)
Authors: Ibrahim Ihsan Taskiran, Stein Aerts
- Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation(2012)
Authors: Bram Van de Sande, Stein Aerts
Pages: 1282 - 1294 - Sequencing the regulatory genome(2008)
Authors: Stein Aerts