Organisation
Laboratory of Computational Biology (VIB-KU Leuven)
Division
Research in the Laboratory of Computational Biology is focusing on gene and genome regulation, with applications in Drosophila and cancer, and on integrative genomics, developing computational methods for genomic data integration and analysis of next-generation sequence data.
Current researchers
1 - 10 of 21 results
- Stein Aerts (Responsible)
- Darina Abaffyová (Member)
- Stein Aerts (Member)
- Sara Aibar Santos (Member)
- Cas Blaauw (Member)
- Carmen Bravo González-Blas (Member)
- Florian De Rop (Member)
- Seppe De Winter (Member)
- Hannah Dickmänken (Member)
- Sam Dieltiens (Member)
Projects
1 - 10 of 64
- Understanding gene regulation in a whole animal: From building a regulatory atlas to decoding gene regulation with deep learningFrom10 Jan 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- SpaceTimeOmics: combining high-throughput spatial omics with AI to model gene regulation in space and timeFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- Interpretation of genomic regulatory variation in the human brain and Parkinson’s Disease by integrating deep learning with single-cell multi-omicsFrom1 Oct 2023 → TodayFunding: FWO junior postdoctoral fellowship
- Deep learning based synthetic design and massively parallel reporter assays to characterize and exploit cell type specific enhancersFrom1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Enhancer-AI: AI-driven modelling and design of cell type specific enhancers for gene therapyFrom1 Oct 2023 → TodayFunding: FWO Strategic Basic Research (SBO)
- Deep learning solutions for deciphering gene regulation in the human brainFrom7 Mar 2023 → TodayFunding: FWO Strategic Basic Research Grant
- The role of smORF encoded polypeptides in lager beer fermentationFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Applications of deep learning for cancer genomicsFrom1 Jan 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Evolution of the genomic regulatory code underlying neuronal diversityFrom1 Oct 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- SymBioSys: Computationally mapping genomic heterogeneity from long read sequencing dataFrom1 Oct 2022 → TodayFunding: BOF - projects
Publications
11 - 20 of 175
- Vision-related convergent gene losses reveal SERPINE3's unknown role in the eye(2022)
Authors: Nikolai Hecker
- Evidence for DBD-LBD communications in the androgen receptor(2012)
Authors: Christine Helsen, Vanessa Dubois, Annelien Verfaillie, Renée Vancraenenbroeck, Marc De Maeyer, Frank Claessens
Pages: 3033 - 3043 - The EMT Transcription Factor ZEB2 Promotes Proliferation of Primary and Metastatic Melanoma While Suppressing an Invasive, Mesenchymal-Like Phenotype(2020)
Authors: Jasper Wouters, David Nittner, Danny Huylebroeck, Joost van den Oord, Chris Marine
Pages: 2983 - 2995 - Biallelic missense variants in ZBTB11 can cause intellectual disability in humans(2018)
Authors: Ibrahim Ihsan Taskiran
Pages: 3177 - 3188 - The PDGFRα-laminin B1-keratin 19 cascade drives tumor progression at the invasive front of human hepatocellular carcinoma(2017)
Authors: Olivier Govaere, Jasper Wouters, Baki Topal, Frederik Nevens, Chris Verslype, Tania Roskams
Pages: 6605 - 6616 - Establishment of the mayfly Cloeon dipterum as a new model system to investigate insect evolution(2019)
Authors: Kristofer Davie, Stein Aerts
- Identification of cis-regulatory modules encoding temporal dynamics during development(2014)
Authors: Delphine Potier, Stein Aerts
Pages: 534 - ORegAnno: an open-access community-driven resource for regulatory annotation(2008)
Authors: Stein Aerts, Peter Van Loo
Pages: D107 - D113 - Comparative motif discovery combined with comparative transcriptomics yield accurate targetome and enhancer predictions(2013)
Authors: Marina Naval Sanchez, Delphine Potier, Sebastian Munck, Bram Van de Sande, Valerie Christiaens, Stein Aerts
Pages: 74 - 88 - LifeTime and improving European healthcare through cell-based interceptive medicine(2020)
Authors: Stein Aerts, Bart De Strooper, Chris Marine, Thierry Voet
Pages: 377 - 386