Organisation
Laboratory of Computational Biology (VIB-KU Leuven)
Division
Research in the Laboratory of Computational Biology is focusing on gene and genome regulation, with applications in Drosophila and cancer, and on integrative genomics, developing computational methods for genomic data integration and analysis of next-generation sequence data.
Projects
31 - 40 of 64
- Novel droplet-microfluidic solutions for single-cell multiomics.From1 Aug 2019 → 30 Sep 2023Funding: FWO Strategic Basic Research Grant
- Transcriptional circuitry of patterning of neural tube organoids and in vivo spinal cordFrom1 Feb 2019 → 30 Jun 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Mapping dynamic transcription factor hierarchies using pooled CRISPR screening with single-cell epigenome readoutFrom1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- SymBioSys: Computationally disentangling cellular heterogeneityFrom1 Oct 2018 → 30 Sep 2022Funding: Fund Recuperation Fiscal Exemption
- Integrating genetic, environmental and developmental variation to study gene regulatory mechanismsFrom18 Jun 2018 → 5 Mar 2021Funding: Own budget, for example: patrimony, inscription fees, gifts
- EXPLORING THE CODE OF LIFE: FROM DECODING TO DESIGNING CELL TYPE-SPECIFIC ENHANCERS WITH DEEP LEARNINGFrom1 May 2018 → 19 Jul 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Single-cell omics in high throughput and at spatial resolutionFrom1 May 2018 → 30 Apr 2022Funding: FWO Medium Size Research Infrastructure
- Mapping regulatory landscapes in the Drosophila brain using single-cell microfluidsFrom11 Sep 2017 → 30 Nov 2022Funding: FWO fellowships
- Reverse engineering cellular identity at single cell resolutionFrom31 Aug 2017 → 7 Feb 2023Funding: FWO fellowships
- Decoding and controlling cell-state switching: A bottom-up approach based on enhancer logicFrom1 Jun 2017 → 31 May 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
1 - 10 of 177
- HIGH-THROUGHPUT SEQUENCING OF THE HUMAN HEPATIC PROGENITOR CELL NICHE REVEALS DIFFERENT SIGNALLING PATHWAYS DEPENDING ON THE UNDERLYING CHRONIC LIVER DISEASE(2015)
Authors: Olivier Govaere, Jasper Wouters, Wouter Van Delm, R van Eijsden, An Ceulemans, Werner Van Steenbergen, Diethard Monbaliu, Frederik Nevens, Tania Roskams
Pages: S239 - S239 - Combined Proteomics and Transcriptomics Identifies Carboxypeptidase B1 and Nuclear Factor κB (NF-κB) Associated Proteins as Putative Biomarkers of Metastasis in Low Grade Breast Cancer(2015)
Authors: Hana Imrichova
Pages: 1814 - 1830 - The protein phosphatase 2A regulatory subunit PR70 is a gonosomal melanoma tumor suppressor gene(2016)
Authors: Jasper Wouters, Joost van den Oord
- Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma(2020)
Authors: Jasper Wouters, Joost van den Oord
- Cancer stem cells in cutaneous melanoma(2009)
Authors: Jasper Wouters, Joost van den Oord, Hugo Vankelecom
Pages: 225 - 235 - Evidence for DNA-Binding Domain-Ligand-Binding Domain Communications in the Androgen Receptor(2012)
Authors: Christine Helsen, Vanessa Dubois, Annelien Verfaillie, Marc De Maeyer, Frank Claessens
Pages: 3033 - 3043 - CD45 antigen negativity in T-lineage ALL correlates with PTPRC mutation and sensitivity to a selective JAK inhibitor(2015)
Authors: Stein Aerts, Ellen Geerdens, Jan Cools
Pages: 884 - 7 - Plasma cells in primary melanoma. Prognostic significance and possible role of IgA(2016)
Authors: Francesca Bosisio, Jasper Wouters, Marguerite Stas, Joost van den Oord
Pages: 347 - 58 - BNIP3 promotes HIF-1α-driven melanoma growth by curbing intracellular iron homeostasis(2021)
Authors: Matteo Rossi, Chris Van den Haute, Maria Livia Sassano, Abhishek Garg, Francesca Bosisio, Jasper Wouters, Peter Vangheluwe, Wim Annaert, Johan Swinnen, Joost van den Oord, et al.
- A Functional In Situ Approach to TILs in Melanoma: A Critique on the Current Morphological Classification(2016)
Authors: Francesca Bosisio, Jasper Wouters, Nathalie Volders, Marguerite Stas, Joost van den Oord
Pages: 126A - 126A