Organisation
Laboratory of Molecullar and Cellular Therapy
Research Group
The focus of the Laboratory for Molecular and Cellular Therapy (LMCT) is directed towards the application of basic immunological knowledge and molecular biotechnology for the understanding, diagnosis and treatment of human diseases, including cancer, infectious disease and brain disease.
Current researchers
1 - 10 of 32 results
- Yannick De Vlaeminck (Responsible)
- Q Lecocq (Responsible)
- Fien Meeus (Responsible)
- Dorien Autaers (Member)
- Robin Maximilian Awad (Member)
- Jonathan Bastos (Member)
- Thomas Benoot (Member)
- Sanne Bevers (Member)
- Karine Breckpot (Member)
- Hannelore Ceuppens (Member)
Projects
1 - 10 of 13
- eveloping microglia replacement therapy to treat progranulinassociated frontotemporal dementiaFrom1 Nov 2022 → TodayFunding: FWO fellowships
- GEAR: Integrating a multimodal approach to address current challenges in immunotherapy (INTEGRAL)From1 Jan 2020 → TodayFunding: IOF - technology validation in real environment, IOF - mandates
- GEAR: Brussels Liver Research to Valorisation Alliance (B-Liver): Valorisation of VUB’s liver cell biology and toxicology expertise via a consortium focused on liver therapeutics, patient and consumer safety.From1 Jan 2020 → TodayFunding: IOF - technology concept exploration, IOF - mandates
- Combining targeted radionuclide therapy and cancer immunotherapy to advance precision medicine through innovation.From1 Nov 2019 → 31 Oct 2021Funding: FWO fellowships
- Eccentric: Enhancing the function of Cancer Countering Effector cells using Nanobodies Targeting Regulatory Immune CheckpointsFrom1 Nov 2019 → 31 Oct 2021Funding: FWO fellowships
- A randomized phase II clinical trial in NSCLC combining SBRT and I.V. anti-PD-1 with or without I.T. anti-CTLA-4/anti-PD-L1 plus CD1c+ myDCFrom1 Oct 2019 → TodayFunding: FWO Applied Biomedical Research (TBM)
- Modulating epigenetic mechanisms to enhance cancer immunotherapy.From1 Oct 2018 → 30 Sep 2022Funding: FWO fellowships
- Inhibition of system xc-: tackling pancreatic cancer from different anglesFrom1 Oct 2018 → 30 Sep 2022Funding: FWO fellowships
- Target and explore the ‘X factor’ of the lung tumor microenvironment.From1 Jan 2018 → 31 Dec 2018Funding: FWO research grant KAN
- Strategic Research Programme: Cancer Cell Targeting in Myeloma and Melanoma (MyMe)From1 Nov 2017 → TodayFunding: University - Project driven research
Publications
1 - 10 of 369
- Inefficient exogenous loading of a tapasin-dependent peptide onto HLA-B*44:02 can be improved by acid treatment or fixation of target cells(2012)
Authors: V. Stroobant, N. Demotte, R. M. Luiten, R. M. Leonhardt, P. Cresswell, Aude Bonehill, A. Michaux, W. Ma, A. Mulder, B.j. Van Den Eynde, et al.
Pages: 1417-1428 - The journey of in vivo virus engineered dendritic cells from bench to bedside(2018)
Authors: Cleo Goyvaerts, Karine Breckpot
Pages: 2052 - Combinatorial strategies for the induction of immunogenic cell death.(2015)
Authors: L Bezu, LC Gomes-de-Silva, Heleen Dewitte, Karine Breckpot, J Fucikova, Radek Spisek, Lorenzo Galluzzi, Oliver Kepp, Guido Kroemer
- Immunomodulatory drugs: new developments(2013)
Authors: Karel Fostier, Ann De Becker, Rik Schots
Pages: 21-28 - Phase I clinical trial of decitabine (5-aza-2 '-deoxycytidine) administered by hepatic arterial infusion in patients with unresectable liver-predominant metastases(2019)
Authors: Yanina Jansen, Gontran Verset, Kelly A Schats, Pieter-Jan van Dam, Teofila Seremet, Mark Kockx, Jean-Luc B. Van Laethem, Bart Neyns
Pages: e000464 - Epitope and HLA-type independent monitoring of antigen-specific T-cells after treatment with dendritic cells presenting full-length tumor antigens(2012)
Authors: An Van Nuffel, Sandra Tuyaerts, Daphné Benteyn, Sofie Wilgenhof, Jurgen Corthals, Carlo Heirman, Bart Neyns, Kristiaan Thielemans, Aude Bonehill
Pages: 23-36 - Dendritic cells loaded with mRNA encoding full-length tumor antigens prime CD4+ and CD8+ T cells in melanoma patients(2012)
Authors: An Van Nuffel, Daphné Benteyn, Sofie Wilgenhof, Lauranne Pierret, Jurgen Corthals, Carlo Heirman, Pierre Van Der Bruggen, Pierre Coulie, Bart Neyns, Kristiaan Thielemans, et al.
Pages: 1063-1074 - Immunotherapy of cancer with dendritic cells loaded with tumorantigen and activated through mRNA electroporation(2010)Series: Methods in Molecular Biology |Volume: 629
Authors: An Van Nuffel, Jurgen Corthals, Bart Neyns, Carlo Heirman, Kristiaan Thielemans, Aude Bonehill
- mRNA: delivering an antitumor message?(2011)
Authors: Sandra Van Lint, Kristiaan Thielemans, Karine Breckpot
Pages: 605-607 - Targeting the tumor microenvironment to enhance antitumor immune responses.(2015)
Authors: Kevin Van der Jeught, Lukasz Bialkowski, Lidia Daszkiewicz, Katrijn Broos, Cleo Goyvaerts, Dries Renmans, Sandra Van Lint, Carlo Heirman, Kristiaan Thielemans, Karine Breckpot
Pages: 1359-1381