Organisation
Laboratory of Molecullar and Cellular Therapy
Research Group
The focus of the Laboratory for Molecular and Cellular Therapy (LMCT) is directed towards the application of basic immunological knowledge and molecular biotechnology for the understanding, diagnosis and treatment of human diseases, including cancer, infectious disease and brain disease.
Current researchers
1 - 10 of 35 results
- Karine Breckpot (Responsible)
- Dorien Autaers (Member)
- Robin Maximilian Awad (Member)
- Jonathan Bastos (Member)
- Thomas Benoot (Member)
- Sanne Bevers (Member)
- Hannelore Ceuppens (Member)
- Céline Coelis (Member)
- Lien De Beck (Member)
- Kirsten De Ridder (Member)
Projects
1 - 10 of 11
- GEAR: Brussels Liver Research to Valorisation Alliance (B-Liver): Valorisation of VUB’s liver cell biology and toxicology expertise via a consortium focused on liver therapeutics, patient and consumer safety.From1 Jan 2020 → TodayFunding: IOF - technology concept exploration, IOF - mandates
- GEAR: Integrating a multimodal approach to address current challenges in immunotherapy (INTEGRAL)From1 Jan 2020 → TodayFunding: IOF - technology validation in real environment, IOF - mandates
- Eccentric: Enhancing the function of Cancer Countering Effector cells using Nanobodies Targeting Regulatory Immune CheckpointsFrom1 Nov 2019 → 31 Oct 2023Funding: FWO fellowships
- Combining targeted radionuclide therapy and cancer immunotherapy to advance precision medicine through innovation.From1 Nov 2019 → 31 Oct 2023Funding: FWO fellowships
- A randomized phase II clinical trial in NSCLC combining SBRT and I.V. anti-PD-1 with or without I.T. anti-CTLA-4/anti-PD-L1 plus CD1c+ myDCFrom1 Oct 2019 → 30 Sep 2023Funding: FWO Applied Biomedical Research (TBM)
- Modulating epigenetic mechanisms to enhance cancer immunotherapy.From1 Oct 2018 → 30 Sep 2022Funding: FWO fellowships
- Target and explore the ‘X factor’ of the lung tumor microenvironment.From1 Jan 2018 → 31 Dec 2018Funding: FWO research grant KAN
- Strategic Research Programme: Cancer Cell Targeting in Myeloma and Melanoma (MyMe)From1 Nov 2017 → TodayFunding: University - Project driven research
- Evaluating a Combination of Immune-based Therapies to Achieve a Functional Cure of HIV Infection (HIVACAR)From1 Jan 2017 → 30 Jun 2022Funding: H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and wellbeing
- Rationally designed therapeutic vaccine against HIV-1 based on a novel formulation of nanoparticle-protected mRNAFrom1 Jan 2016 → 31 Dec 2018Funding: FWO research project (including WEAVE projects)
Publications
1 - 10 of 333
- A galectin-3 ligand corrects the impaired function of human CD4 and CD8 tumor-infiltrating lymphocytes and favors tumor rejection in mice
Authors: N. Demotte, , P. Van Der Smissen, M. Moser, Schmidt C.w., Kris Thielemans, Squifflet J.l., B Weynand, J. Carrasco, C. Lurquin, et al.
Pages: 7476-7488 - Sirtuin 1 promotes Th2 responses and airway allergy by repressing peroxisome proliferator-activated receptor-Œ≥ activity in dendritic cells
Authors: A. Legutko, T. Marichal, L. Fiévez, D. Bedoret, A. Mayer, H. De Vries, L. Klotz, P.v. Drion, Carlo Heirman, D. Cataldo, et al.
Pages: 4517-4529 - MAGE-A3 and MAGE-A4 specific CD4(+) T cells in head and neck cancer patients: detection of naturally acquired responses and identification of new epitopes.
Authors: V Cesson, Jp Rivals, A Escher, E Piotet, Kris Thielemans, V Posevitz, D Dojcinovic, P Monnier, D Speiser, L Bron, et al.
Pages: 23-35 - Direct parametric reconstruction from dynamic projection data in emission tomography including prior estimation of the blood volume component.
Authors: C. Tsoumpas, Kris Thielemans
Pages: 490-493 - Cellular immunotherapy in multiple myeloma: Lessons from preclinical models(2014)
Authors: Marilene Binsfeld, Karel Fostier, J. Muller, F. Baron, Henri Schots, Yves Beguin, R Heusschen, Jo Caers
Pages: 392-404 - Carfilzomib: a novel treatment in relapsed and refractory multiple myeloma(2012)
Authors: Karel Fostier
Pages: 237-244 - Expansion of polyfunctional HIV-specific T cells upon stimulation with mRNA electroporated dendritic cells in the presence of immunomodulatory drugs(2012)
Authors: Brenda De Keersmaecker, Sabine D Allard, P Lacor, Henri Schots, Kris Thielemans, Joeri L Aerts
Pages: 9351-9360 - Localised abdominal compartment syndrome(2010)
Authors: Inneke E De Laet, Angelo Willems, Niels van Regenmortel, Karen Schoonheydt, Hilde Dits
Pages: 98-106 - Recent advances using genetic therapies against infectious diseases and for vaccination(2023)
Authors: Anne Galy, Ben Berkhout, Karine Breckpot, Chantal Pichon, Kristie Bloom, Hans-Peter Kiem, Michael D Mühlebach, Joseph M McCune
Pages: 896-904 - Challenges in neoantigen-directed therapeutics(2023)
Authors: Lien Lybaert, Steve Lefever, Bruno Fant, Evelien Smits, Bruno De Geest, Karine Breckpot, Luc Dirix, Steven A Feldman, Wim Van Criekinge, Kris Thielemans, et al.
Pages: 15-40