Organisation
Laboratory of Synapse Biology (VIB-KU Leuven)
Lab
The Laboratory of Synapse Biology aims to unravel the molecular mechanisms that control neuronal connectivity in developing circuits, and determine how perturbations in this process affect cognitive function.
Current researchers
1 - 10 of 15 results
- Joris de Wit (Responsible)
- Lucas Baltussen (Member)
- Stephanie Chanda (Member)
- Danie Daaboul (Member)
- Dan Dascenco (Member)
- Cydric Geyskens (Member)
- Efstathia Artemis Koumoundourou (Member)
- Elke Leysen (Member)
- Blanca Lorente Echeverría (Member)
- Gabriele Marcassa (Member)
Projects
1 - 10 of 34
- Enhancer-AI: AI-driven modelling and design of cell type specific enhancers for gene therapyFrom1 Oct 2023 → TodayFunding: FWO Strategic Basic Research (SBO)
- Microglia-synapse molecular interactions in Alzheimer's diseaseFrom1 Oct 2022 → TodayFunding: FWO junior postdoctoral fellowship
- Unravelling the regulatory code orchestrating neural circuit formationFrom5 Oct 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Resilience and vulnerability in the cellular phase of Alzheimer’s disease.From1 Oct 2021 → TodayFunding: BOF - Methusalem
- Development and Specification of Cortical Layer 1 MicrocircuitsFrom1 Sep 2021 → 22 Feb 2024Funding: Own budget, for example: patrimony, inscription fees, gifts
- Role of cell-surface receptor signaling mechanisms in dendritic spine maturation and plasticityFrom26 Aug 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Synapse type-specific multi-omics mapping of sensory experience-induced plasticityFrom1 Nov 2020 → 31 Dec 2022Funding: FWO junior postdoctoral fellowship
- Mapping of input-specific protein repertoires using state-of-the art genome engineering and imaging tools.From1 Oct 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Mapping the synaptic proteome through site-specific protein biotinylationFrom1 Oct 2020 → 30 Sep 2023Funding: FWO senior postdoctoral fellowship
- Mapping the cell-surface molecule repertoires patterning hippocampal CA1 border interneuron connectivityFrom15 Sep 2020 → TodayFunding: FWO fellowships
Publications
1 - 10 of 71
- Age and inhibition: determinants of cross-modal plasticity in the visual cortex of the mouse (Mus musculus)(2013)
Authors: Julie Nys, Lut Arckens
Number of pages: 197 - The Yeast P5 Type ATPase, Spf1, Regulates Manganese Transport into the Endoplasmic Reticulum
Authors: Giuseppe Condomitti
- Regional specificity of GABAergic regulation of cross-modal plasticity in mouse visual cortex upon unilateral enucleation(2015)
Authors: Julie Nys, Katrien Smolders, Marie-Eve Laramée, Isabel Hofman, Tjing Hu, Lut Arckens
Pages: 11174 - 11189 - Binocular pattern depriviation interferes with the expression of proteins involved in primary visual cortex maturation in the cat(2015)
Authors: Julie Nys, Tjing Hu, Lut Arckens
Pages: 1 - 18 - AMIGO2 mRNA expression in hippocampal CA2 and CA3a(2012)
Authors: Annelies Laeremans, Julie Nys, Walter Luyten, Rudi D'Hooge, Melissa Paulussen, Lut Arckens
Pages: 123 - 130 - S-Nitrosylation of Ras Mediates Nitric Oxide-Dependent Post-Injury Neurogenesis in a Seizure Model(2017)
Authors: Alicia Izquierdo-Alvarez, Luís Filipe da Silva Ribeiro
Pages: 15 - 30 - Visual system plasticity in mammals: the story of enucleation-induced vision loss(2015)
Authors: Julie Nys, Isabelle Scheyltjens, Lut Arckens
Pages: 1 - 20 - Ecto-Fc MS identifies ligand-receptor interactions through extracellular domain Fc fusion protein baits and shotgun proteomic analysis(2014)
Authors: Joris de Wit
Pages: 2061 - 2074 - Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model(2020)
Authors: Gabriele Marcassa, Iordana Chrysidou, Joris de Wit, Bart De Strooper
- Role of regulatory C-terminal motifs in synaptic confinement of LRRTM2(2021)
Authors: Joris de Wit
Pages: 492 - 506