Organisation
Laboratory of Synapse Biology (VIB-KU Leuven)
Lab
The Laboratory of Synapse Biology aims to unravel the molecular mechanisms that control neuronal connectivity in developing circuits, and determine how perturbations in this process affect cognitive function.
Current researchers
1 - 10 of 16 results
- Joris de Wit (Responsible)
- Lucas Baltussen (Member)
- Stephanie Chanda (Member)
- Danie Daaboul (Member)
- Dan Dascenco (Member)
- Cydric Geyskens (Member)
- Efstathia Artemis Koumoundourou (Member)
- Elke Leysen (Member)
- Blanca Lorente Echeverría (Member)
- Gabriele Marcassa (Member)
Projects
1 - 10 of 34
- Enhancer-AI: AI-driven modelling and design of cell type specific enhancers for gene therapyFrom1 Oct 2023 → TodayFunding: FWO Strategic Basic Research (SBO)
- Microglia-synapse molecular interactions in Alzheimer's diseaseFrom1 Oct 2022 → TodayFunding: FWO junior postdoctoral fellowship
- Unravelling the regulatory code orchestrating neural circuit formationFrom5 Oct 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Resilience and vulnerability in the cellular phase of Alzheimer’s disease.From1 Oct 2021 → TodayFunding: BOF - Methusalem
- Development and Specification of Cortical Layer 1 MicrocircuitsFrom1 Sep 2021 → 22 Feb 2024Funding: Own budget, for example: patrimony, inscription fees, gifts
- Role of cell-surface receptor signaling mechanisms in dendritic spine maturation and plasticityFrom26 Aug 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Synapse type-specific multi-omics mapping of sensory experience-induced plasticityFrom1 Nov 2020 → 31 Dec 2022Funding: FWO junior postdoctoral fellowship
- Mapping of input-specific protein repertoires using state-of-the art genome engineering and imaging tools.From1 Oct 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Mapping the synaptic proteome through site-specific protein biotinylationFrom1 Oct 2020 → 30 Sep 2023Funding: FWO senior postdoctoral fellowship
- Mapping the cell-surface molecule repertoires patterning hippocampal CA1 border interneuron connectivityFrom15 Sep 2020 → TodayFunding: FWO fellowships
Publications
1 - 10 of 68
- Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation(2021)
Authors: Luís Filipe da Silva Ribeiro
- Extracellular Sphingosine-1-Phosphate: A Novel Actor in Human Glioblastoma Stem Cell Survival
Authors: Giuseppe Condomitti
- A Highly Reproducible and Straightforward Method to Perform In Vivo Ocular Enucleation in the Mouse after Eye Opening(2014)
Authors: Jeroen Aerts, Julie Nys, Lut Arckens
- The cross-modal aspect of mouse visual cortex plasticity induced by monocular enucleation is age dependent(2014)
Authors: Julie Nys, Jeroen Aerts, Ellen Ytebrouck, Samme Vreysen, Annelies Laeremans, Lut Arckens
Pages: 950 - 970 - Altered neuronal architecture and plasticity in the visual cortex of MMP-3 deficient mice(2013)
Authors: Jeroen Aerts, Julie Nys, Katrien Smolders, Tjing Hu, Lieve Moons, Lut Arckens
Pages: 2675 - 2689 - Cell-Intrinsic Requirement of Dscam1 Isoform Diversity for Axon Collateral Formation(2014)
Authors: Azadeh Izadifar, Olivier Urwyler, Bing Yan, Maria-Luise Erfurth, Dan Dascenco, Dietmar Schmucker
Pages: 1182 - 6 - Slit and Receptor Tyrosine Phosphatase 69D Confer Spatial Specificity to Axon Branching via Dscam1(2015)
Authors: Dan Dascenco, Maria-Luise Erfurth, Azadeh Izadifar, Sonja Sachse, Olivier Urwyler, Dietmar Schmucker
Pages: 1140 - 1154 - Leucine-rich repeat protein diversity in synapse and circuit function(2018)
Authors: Anna Schroeder, Joris de Wit
- The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors(2015)
Authors: Luís Filipe da Silva Ribeiro, Heather Rice, Joris de Wit
Pages: 764 - 780 - Proteomics-based synapse characterization: From proteins to circuits(2023)
Authors: Dan Dascenco, Joris de Wit