Organisation
Laboratory of Translational Genetics (VIB-KU Leuven)
The overall aim of the research of the Laboratory of Translational Genetics, is to unravel the genetic predisposition to cancer and to annotate somatic changes in solid tumors with the ultimate aim to discover and functionally validate genetic biomarkers for cancer therapies.
Current researchers
1 - 9 of 9 results
- Diether Lambrechts (Responsible)
- Ayse Bassez (Member)
- Dóra Bihary (Member)
- Chen Gu (Member)
- Aurelie Mechels (Member)
- Junbin Qian (Member)
- Heesoo Song (Member)
- Pierre Van Mol (Member)
- Sam Vanmassenhove (Member)
Projects
1 - 10 of 77
- Analysis of the immune response in cancer patients treated with immune checkpoint blockade therapies, focusing on the antigenic landscape recognized by expanding tumorinfiltrating T cells in lung cancer patientsFrom15 Nov 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Spatial and single-cell RNA sequencing Transcriptomics Reveal the Heterogeneous Landscape and Microenvironment of Primary Urethral Squamous Cell CarcinomaFrom11 Oct 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Advanced image analysis to predict response to immune check point blockade in breast cancer (ref. BAP-2023-787).From4 Jun 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Liquid biopsy and HRD testing in ovarian cancerFrom4 Oct 2023 → TodayFunding: Foundations, funds and other with scientific goal
- Advancing Penile, Vulvar and Urethral Squamous Cell Carcinoma management by identifying tissue and blood-based signals for chemo-immunotherapy response.From1 Oct 2023 → TodayFunding: FWO fellowships
- Refinement of candidate predictive biomarkers for response to immune checkpoint inhibition in hepatocellular carcinomaFrom1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- High-resolution spatial maps of the tumor microenvironment during checkpoint immunotherapyFrom9 May 2023 → TodayFunding: FWO Strategic Basic Research Grant
- An Integrated Spatial Atlas of the Tumor Micro-environment of Early Non-Small Cell Lung CancerFrom16 Mar 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Abemaciclib and letrozole in ER positive rare ovarian cancerFrom1 Mar 2023 → TodayFunding: Foundations, funds and other with scientific goal
- SymBioSys: Computationally mapping genomic heterogeneity from long read sequencing dataFrom1 Oct 2022 → TodayFunding: BOF - projects
Publications
1 - 10 of 651
- Methylation Defect in Imprinted Genes Detected in Patients with an Albright's Hereditary Osteodystrophy Like Phenotype and Platelet Gs Hypofunction(2012)
Authors: Benedetta Izzi, Inge Francois, Veerle Labarque, Koenraad Devriendt, Eric Legius, Diether Lambrechts, Francis de Zegher, Chris Van Geet, Kathleen Freson
- Predictors of pretreatment CA125 at ovarian cancer diagnosis: a pooled analysis in the Ovarian Cancer Association Consortium(2017)
Authors: Diether Lambrechts
Pages: 459 - 468 - Patch based super-resolution of MR spectroscopic images(2016)
Authors: Saurabh Jain, Diana Sima, Sabine Van Huffel, Frederik Maes, Dominiek Smeets
Pages: 452 - 456 - PHIP - a novel candidate breast cancer susceptibility locus on 6q14.1(2017)
Authors: Bram Boeckx, Diether Lambrechts
Pages: 102769 - 102782 - Chromosomal instability in cell-free DNA as a highly specific biomarker for detection of ovarian cancer in women with adnexal masses(2017)
Authors: Adriaan Vanderstichele, Pieter Busschaert, Dominiek Smeets, Chiara Landolfo, Els Van Nieuwenhuysen, Patrick Neven, Frédéric Amant, An Coosemans, Dirk Timmerman, Diether Lambrechts, et al.
Pages: 2223 - 2231 - Split-BioID: a proximity-biotinylation assay for dimerization-dependent protein interactions(2017)
Authors: Sofie De Munter, Janina Goernemann, Rita Derua, Junbin Qian, Ewald Heroes, Etienne Waelkens, Aleyde Van Eynde, Monique Beullens, Mathieu Bollen
Pages: 415 - 424 - An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression(2016)
Authors: Diether Lambrechts, Hans Wildiers
Pages: 3863 - 3876 - Genomic signatures as predictive biomarkers of homologous recombination deficiency in ovarian cancer(2017)
Authors: Adriaan Vanderstichele, Pieter Busschaert, Siel Olbrecht, Diether Lambrechts, Ignace Vergote
Pages: 5 - 14 - Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2(2015)
Authors: Diether Lambrechts, Matthieu Moisse, Beppe Floris, Benoit Beuselinck
Pages: 2966 - 84 - Identification of novel genetic markers of breast cancer survival(2015)
Authors: Diether Lambrechts, Caroline Weltens, Karin Leunen