Organisation
Laboratory of Tumor Inflammation and Angiogenesis (VIB-KU Leuven)
Division
The Lab of Molecular Oncology and Angiogenesis aims to shed light on the genetic and molecular mechanisms that regulate vessel shape remodeling and endothelial cell fate, with the overall aim of defining alternative therapeutic opportunities to improve anti-cancer therapy, as well as therapeutic angiogenesis for revascularization of ischemic tissues.
Current researchers
1 - 7 of 7 results
- Max Mazzone (Responsible)
- Emanuele Berardi (Member)
- Marie-Pauline Orban (Member)
- Carla Riera Domingo (Member)
- Silvia Rivis (Member)
- Tommaso Scolaro (Member)
- Shikang Zhao (Member)
Projects
1 - 10 of 68
- Targeting the DNA methylation profile of cytotoxic T cells to overcome immunotherapy resistance of pancreatic cancerFrom5 Mar 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Understanding glutamate metabolism in the tumor microenvironment to tackle Immune Checkpoint Blockade (ICB) resistanceFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- Role of SLC1A3 in tumor-associated macrophages during immunotherapy resistance onset in breast cancerFrom1 Oct 2023 → TodayFunding: Foundations, funds and other with scientific goal
- Targeting the CDA/P2Y6 axis to overcome immunosuppression and favor response to immune checkpoint inhibitors in pancreatic cancerFrom1 Jul 2023 → TodayFunding: Other federal public and semi-governmental institutions
- Tackling tumor immunosuppression by reprograming eicosanoid metabolism and signaling in the tumor microenvironmentFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Tackling SLC1A3 in tumor-associated macrophages to overcome anti-PD1 immunotherapy resistance in breast cancerFrom31 Oct 2022 → TodayFunding: FWO Strategic Basic Research Grant
- LipoMacs: functional Lipidomics to unlock Macrophage-mediated therapyFrom1 Oct 2022 → TodayFunding: FWO Strategic Basic Research (SBO)
- BD Imaging Cell Sorter – BD Cell View TechnologyTMFrom24 Jun 2022 → TodayFunding: Other federal scientific institutions
- Tricking tumor immunosuppression: RNA epigenetics as novel target to improve cancer immunotherapyFrom1 Jan 2022 → TodayFunding: FWO EOS
- Duchenne muscular dystrophy.From1 Jan 2022 → 31 Dec 2022Funding: Nonprofit institution or equivalents
Publications
1 - 10 of 314
- Inhibition of Endothelial NOTCH1 Signaling Attenuates Inflammation by Reducing Cytokine-Mediated Histone Acetylation at Inflammatory Enhancers.(2018)
Authors: Manuel Ehling
Pages: 854 - 869 - Role of miRNAs in tumor and endothelial cell interactions during tumor progression(2020)
Authors: Francesca Orso, Lorena Quirico, Daniela Dettori, Roberto Coppo, Federico Virga, Livia C Ferreira, Camilla Paoletti, Desiree Baruffaldi, Elisa Penna, Daniela Taverna
Pages: 214 - 224 - Investigating the epi-miRNome: identification of epi-miRNAs using transfection experiments(2019)
Authors: Elisa Reale, Daniela Taverna, Laura Cantini, Loredana Martignetti, Matteo Osella, Cristiano De Pitta, Federico Virga, Francesca Orso, Michele Caselle
Pages: 1581 - 1599 - IL-17A and IL-17F orchestrate macrophages to promote lung cancer(2020)
Authors: Nathalia Ferreira, Ines Mesquita, Fatima Baltazar, Ricardo Silvestre, Sara Granja
Pages: 643 - 654 - Establishment and Characterization of a New Intrahepatic Cholangiocarcinoma Cell Line Resistant to Gemcitabine(2019)
Authors: Chiara Varamo
- Hyperactive piggyBac transposons for sustained and robust liver-targeted gene therapy.(2014)
Authors: Mario di Matteo
Pages: 1614 - 1624 - 1,25 dihydroxyvitamin D3 curtails the inflammatory- and T cell stimulatory capacity of macrophages through an IL-10-dependent mechanism(2012)
Authors: Hannelie Korf, Mathias Wenes, Tatiana Takiishi, Sofie Robert, Conny Gysemans, Chantal Mathieu
Pages: 1292 - 1300 - Nucleolar localization of the ErbB3 receptor as a new target in glioblastoma(2022)
Authors: Rosa Trotta
- SLC25A26 overexpression impairs cell function via mtDNA hypermethylation and rewiring of methyl metabolism(2017)
Authors: Max Mazzone
Pages: 967 - 984 - c-MET dependent neutrophil responses limit anti-tumoral T cell expansion and immunotherapy of cancer(2017)
Authors: Max Mazzone
Pages: E93 - E94