Organisation
Laboratory of Tumor Inflammation and Angiogenesis (VIB-KU Leuven)
Division
The Lab of Molecular Oncology and Angiogenesis aims to shed light on the genetic and molecular mechanisms that regulate vessel shape remodeling and endothelial cell fate, with the overall aim of defining alternative therapeutic opportunities to improve anti-cancer therapy, as well as therapeutic angiogenesis for revascularization of ischemic tissues.
Projects
21 - 30 of 68
- Exploring mechanisms of immunotherapy resistance in pancreatic cancerFrom3 May 2019 → 16 Feb 2021Funding: Own budget, for example: patrimony, inscription fees, gifts
- Integrated IMMUnoprofiling of large adaptive CANcer patients cohortsFrom1 Mar 2019 → TodayFunding: H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and wellbeing, H2020 - European Institute of Innovation and Technology
- Exploring the role of PlexinA4 in cytotoxic T cells: insights for antitumor immune response & cancer immunotherapyFrom1 Feb 2019 → 31 Oct 2023Funding: FWO fellowships, Foundations, funds and other with scientific goal
- Metabolic editing of the tumor microenvironment as a novel strategy to abate immunosuppressionFrom1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- Exploring the role of PlexinA4 in cytotoxic T cells: insights for antitumor immune response & cancer immunotherapyFrom1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- Harnessing tumor metabolism to overcome immunosupressionFrom1 Jul 2018 → 30 Jun 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Mass cytometry by time-of-flight: next-generation flow cytometry for multiplexed single cell analysisFrom1 May 2018 → 30 Apr 2022Funding: FWO Medium Size Research Infrastructure
- Harnessing the intrinsic metabolism of CD8+ T cells to improve their anti-tumor immune responseFrom5 Feb 2018 → 31 Oct 2023Funding: FWO Strategic Basic Research Grant, Foundations, funds and other with scientific goal
- MATATUM: Validation and druggability development of macrophage-specific targets in the tumor microenvironment.From1 Jan 2018 → 31 Dec 2021Funding: FWO Strategic Basic Research (SBO)
- A metabolic gene survey pinpoints fucosylation as a key pathway underlying the suppressive function of Regulatory T cells in cancer.From21 Sep 2017 → 16 May 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
1 - 10 of 314
- Modulating chitosan-PLGA nanoparticle properties to design a co-delivery platform for glioblastoma therapy intended for nose-to-brain route(2020)
Authors: Natalia N Ferreira, Sara Granja, Fernanda Boni, Fabiola G Prezotti, Leonardo MB Ferreira, Beatriz SF Cury, Rui M Reis, Fatima Baltazar, Maria Palmira D Gremiao
Pages: 1729 - 1747 - Crosstalk between glial and glioblastoma cells triggers the "go-or-grow" phenotype of tumor cells(2017)
Authors: Ana Ferreira de Oliveira, Sandra I Anjo, Joana Vieira de Castro, Sofia C Serra, Antonio J Salgado, Bruno Manadas, Bruno M Costa
- PD-1/PD-L1 immune checkpoint inhibitors in neoadjuvant therapy for solid tumors (Review)(2023)
Authors: Shikang Zhao
- A NEW ROLE FOR MMP-10 IN PATIENTS WITH PERIPHERAL ARTERY DISEASE AND EXPERIMENTAL ARTERIAL ISCHEMIA(2014)
Authors: Max Mazzone
Pages: E161 - E161 - The impact of hypoxia on tumor-associated macrophages(2016)
Authors: Anne-Theres Henze, Max Mazzone
Pages: 3672 - 3679 - Hypoxia-induced miR-210 modulates the inflammatory response and fibrosis upon acute ischemia (vol 12, 435, 2021)(2021)
Authors: Germana Zaccagnini, Simona Greco, Marialucia Longo, Biagina Maimone, Christine Voellenkle, Paola Fuschi, Matteo Carrara, Pasquale Creo, Davide Maselli, Mario Tirone, et al.
- Neuropilin 1 and its inhibitory ligand mini-tryptophanyl-tRNA synthetase inversely regulate VE-cadherin turnover and vascular permeability(2022)
Authors: Max Mazzone
- The anti-proliferative effect of L-carnosine correlates with a decreased expression of hypoxia inducible factor 1 alpha in human colon cancer cells(2014)
Authors: Max Mazzone
- Loss of Caveolin-1 in Metastasis-Associated Macrophages Drives Lung Metastatic Growth through Increased Angiogenesis(2017)
Authors: Ward Celus, Manuel Ehling, Max Mazzone
Pages: 2842 - 2854 - Understanding Metal Dynamics Between Cancer Cells and Macrophages: Competition or Synergism?(2020)
Authors: Max Mazzone