Reproduction and Genetics
The core business of REGE is the interphase between reproduction and genetics, a wide discipline covering several subdisciplines. Male infertility and the search for genes involved in spermatogenensis is a first topic that is mainly investigated within the Centre for Medical Genetics. A second important topic covers the (epi)genetics of embryos and embryonic stem cells, amongst others the investigation of chromosomal abnormalities, epigenetic changes and the development of embryonic stem cells carrying a monogenic disease as disease models. Through our intensive collaboration with the Centre for Reproductive Medicine , we have a special interest in human embryology with topics such as the pluripotency of preimplantation embryos and the comparison with embryonic stem cells, cryobiology and the follow-up of childran born after medically assisted reproduction. The clinical activity within the CRG with continuing development of new infertility treatments and monitoring and fine-tuning of existing infertility treatments has for years been extremely active and internationally recognised. As historically developed activity, we have a link with neuropaeditrics for the investigation of mitochondrial pathologies and cortical malformations. More recently, and with the arrival of Prof Brugada at our campus, an activity in cardiogenetics has been set up. The interphase between genetics and reproduction is a specific hybrid branch of biomedical sciences in which the VUB and our group excel.