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Organisation

VIB CMN - Applied and Translational Neurogenomics

Research Group

Lifecycle:1 Jan 2020 →  Today
Organisation profile:Frontotemporal Dementia (FTD) represents 10-20% of all dementias and is clinically important because of its early onset and its dramatic impact on core human qualities, including personality, insight and verbal communication. Research in our group is focused on the discovery and functional characterization of novel disease genes implicated in FTD and related disorders. Our group leads world-wide consortia focused on two important pathological subtypes of FTD. Starting from blood or brain tissue samples, we combine genomic, transcriptomic, epigenomic and proteomic analyses to identify genes and pathways implicated in disease. We also leverage our genetic findings to further the understanding of FTD and related disorders through the generation of cell and mouse models. Together our findings provide new insight into the pathomechanisms underlying FTD and contribute to the development of biomarkers and to the identification new targets for neurodegenerative disease therapies.
Keywords:NEUROGENETICS, NEURODEGENERATION, DISEASE MODELS, BIOINFORMATICS, FRONTOTEMPORAL DEMENTIA
Disciplines:Bioinformatics and computational biology, Diagnostics, Medical systems biology, Molecular and cell biology, Neurosciences, Regenerative medicine