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Organisation

VIB CMN - Genetics of Alzheimer’s Disease

Research Group

Lifecycle:1 Oct 2020 →  Today
Organisation profile:The research unit is committed to increase insight in the complex genetics of Alzheimer's disease and to investigate the translational potential of genetic discovery. We use genetic-epidemiological methods and advanced genomic technologies to identify molecular mechanisms that can serve as future targets for early detection, prevention and treatment. Techniques include 2nd and 3rd generation DNA and RNA sequencing on various biomaterials, ranging from targeted through whole exome to whole genome sequencing and in situ sequencing, high-throughput association studies (both common and rare, SNP and CNV) on disease endpoints as well as intermediate and endophenotypes, identification of genetic factors that modify onset age, and polygenic risk profiling. We participate in numerous (inter-) national networks and consortia, to enhance gene identification, interdisciplinary gene characterization and early biomarker discovery.
Keywords:ALZHEIMER'S DISEASE, RARE VARIANTS, GENETICS, TRANSCRIPTOMICS, GENETIC EPIDEMIOLOGY, POLYGENIC RISK SCORE
Disciplines:Genetics, Medical systems biology, Neurosciences, Public health sciences, Bioinformatics and computational biology