< Back to previous page
Patent
A method and a system for analysis of cardiomyocyte function
A method for analysis of cardiomyocyte function comprises: receiving (302) in a measurement position a substrate (110) carrying cardiomyocytes on a cell culturing surface; recording (304) electrical signals from the cardiomyocytes; simultaneously with said recording, acquiring (306) a sequence of images of the cardiomyocytes on the cell culturing surface based on detecting light wavefront information of reflected light; determining (308) an electrical representation relating to an intracellular and/or extracellular action potential, and/or an impedimetric electrical image of a cardiomyocyte based on the recorded electrical signals; and determining (310) a contractile representation relating to cellular deformation during contractility action of a group of cardiomyocytes based on the acquired sequence of images, wherein the electrical representation and the contractile representation apply to a common period of time.
Patent Publication Number: WO2019121934
Year filing: 2019
Year approval: 2020
Year publication: 2019
Status: Requested
URI: link to Espacenet
Technology domains: Digital communication, Analysis of biological materials, Biotechnology
Validated for IOF-key: Yes
Attributed to: Associatie KULeuven