Adolescent obesity; what determines endothelial dysfunction and is the process reversible?

Endothelial dysfunction is already manifest in obese children. Physical activity and diet are efficient measures to tackle obesity. 2 cohorts of obese adolescents are recruted dietary advise and encouragement of sports vs supervised diet and training (10 mths). Improved endothelial-dependent vasodilation serves as a primary endpoint. Metabolic/inflammatory changes, oxidative stress, mobilisation/function of endothelial progenitor cells (endothelial repair) is examined. Endothelial damage is assessed through liberation of endothelial microparticles.

Keywords:ADOLESCENTS, EXERCISE PHYSIOLOGY, OBESITY, ENDOTHELIUM

Disciplines:Cardiac and vascular medicine, Orthopaedics, Human movement and sports sciences, Rehabilitation sciences

Project type:Collaboration project