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Airborne soot particles and adverse renal outcomes: translocation, kidney functioning and renal graft outcome (R-11202)

Outdoor air pollution poses a significant public health risk. Yet, insight into the impact of soot particles, one of the most toxic components of air pollution, on organs other than the lung is scarce. Recently, our research group confirmed soot translocation from the systemic circulation to the urine of healthy individuals. Accordingly, the aims of this project are (i) to study the bioaccumulation of soot particles inside the kidneys and excretion into the urine, (ii) to deduce their role in the development/exacerbation of impaired kidney function and (iii) to investigate whether the particles have an adverse effect on renal allograft outcome. To ensure detailed information the aims are examined on different biological levels. First, the translocation, bioaccumulation, and excretion of inhaled soot particles are examined in murine and human kidney tissues and urine using our state-of-the-art label-free detection method. Second, using the same renal tissues, potentially disturbed kidney function is evaluated in direct association with the accumulation sites of soot particles. Third, urinary markers related to kidney functioning are studied in the function of soot exposure. Finally, the association between ambient soot exposure and allograft outcome is evaluated in human kidney transplant recipients. Overall, the results of this project will lead to a better understanding of the health risks for the general public and kidney transplant recipients associated with soot exposure.
Date:1 Nov 2020  →  Today
Keywords:AIR POLLUTION, Kidney diseases
Disciplines:Other environmental sciences not elsewhere classified, Kidney diseases, Kidney transplantation, Epidemiology, Biomarker evaluation