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Analysis of kynurenines in serum of bipolar patients and their association with affective and cognitive symptoms.
This project will evaluate the association of an upregulated kynurenine pathway with the clinical symptomatology in bipolar disorder (BD). Therefore, an analytical method based on liquid chromatography-mass spectrometry will be developed for the detection of kynurenines in serum. The method will be applied on samples from BD patients in parallel with mood state monitoring. Project results could aid in a better understanding of BD pathophysiology.
Date:1 Feb 2015 → 31 Dec 2015
Keywords:KYNURENINE, LC-MASS SPECTROMETRY, CLINICAL CHEMISTRY, BIPOLAR DISORDER
Disciplines:Laboratory medicine, Medical systems biology, Psychiatry and psychotherapy, Nursing, Other paramedical sciences, Medicinal chemistry, Clinical and counseling psychology, Other psychology and cognitive sciences