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Project
Biogeography of plethodontid salamanders reflects origin and evolution of antimicrobial skin defenses against lethal chytridiomycosis
This research focusses on how antimicrobial peptides (AMP) in skin secretions of plethodontid salamanders cause resistance for chytridiomycosis and how these peptides have evolved. Consequently the AMP arsenal in 3 plethodontid model species will be explored as well as, the mode of action of potent AMP’s at cellular level and the distribution of genes encoding for potent AMP’s.
Date:1 Oct 2013 → 30 Sep 2016
Keywords:amphibia, chytridiomycosis, skin secretions, Batrachochytrium dendrobatidis, resistance, antimicrobial peptides
Disciplines:Medical biochemistry and metabolism, Animal biology, Veterinary medicine, Laboratory medicine, Microbiology, Other veterinary sciences, Other agricultural, veterinary and food sciences, Systems biology, Biochemistry and metabolism