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Project

Characterization of the distinct impact of one-eyed vision on monocular cortex: a molecular, cellular and systems level analysis of cross-modal brain plasticity in the adult mouse

One of the best-studied examples of experience- and age-dependent modifications of neuronal circuits in the brain is ocular dominance plasticity. Although it is involved in the reactivation of the binocular visual cortex after the loss of one eye, it does not explain the recovery of the simultaneously deprived monocular zone. This suggests brain region-specific modifications of the circuitry and/or molecular pathways to cope with the sensory deprivation. Cross-modal plasticity through other sensory modalities can reactivate deprived cortex but the anatomical pathways are not known in detail. In this project, we will identify their precise location to perform pathwayspecific activation and inactivation in order to determine the exact contribution of whisker inputs to the activation of visually deprived areas in the mouse. We will also determine the underlying molecular mechanisms responsible for the observed cortical zone-specific recovery in order to identify potential pharmacological targets to potentiate/suppress cross-modal inputs. Their behavioral relevance will also be investigated. In sum, this project will thus shed light on the structural, molecular, functional and behavioral aspects of cross-modal plasticity in the mammalian brain as a basis towards effective therapy for multisensory integration deficits.

Date:1 Jan 2016 →  31 Dec 2019
Keywords:molecular, cellular, systems level, distinct impact, one-eyed vision, monocular cortex, adult mouse, brain plasticity, cross-modal
Disciplines:Animal biology, Other agricultural, veterinary and food sciences