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Project

The exploration of inorganic nanoparticle delivery to solid tumors and their therapeutic potential

The first project involves designing nanocarriers for the targeted delivery of chemotherapies to MRC-1 expressing tumor-associated macrophages (TAMs) that harbour angiogenic and immunosuppressive properties and promote tumor growth. The efficacy of the nanocarrier-drug construct uptake by the TAMs will be evaluated based on the genetic expression of an internally developed viral recombination system encapsulated within these nanoparticles and intravenously injected in animal models. Another project aims to investigate the role of the tumor immune environment in the uptake efficacy of nanoparticles by tumor cells via a newly discovered transcytosis transport pathway.

Date:7 May 2019 →  15 Dec 2023
Keywords:Nanotechnology, Immunotherapy, Cancer
Disciplines:Cancer therapy, Medical nanotechnology, Nanobiotechnology
Project type:PhD project